San Francisco 49ers
- EDGE Nick Bosa, torn ACL
- DL Solomon Thomas, unknown knee injury
- RB Raheem Mostert, knee
- QB Jimmy Garoppolo, ankle
- C Connor McGovern, hamstring
- WR Breshad Perriman, ankle
- RB Christian McCaffrey, high ankle sprain, out 2-6 weeks
- RB Saquon Barkley, torn ACL
- WR Sterling Shepard, toe
- QB Drew Lock, shoulder
- WR Courtland Sutton, knee
- Malik Hooker, achilles
- WR Parris Campbell
- QB Tyrod Taylor, chest
- LB Anthony Barr, torn pec